Article

ALS patient-derived motor neuron networks exhibit microscale dysfunction and mesoscale compensation rendering them highly vulnerable to perturbation

2024-01-04

Abstract excerpt

<h4>Summary</h4> Amyotrophic lateral sclerosis affects upper and lower motor neurons, causing progressive neuropathology leading to structural and functional alterations of affected neural networks long prior to development of symptoms. Certain genetic mutations, such as expansions in C9orf72 , predispose motor neuron populations to pathological dysfunction. However, it is not known how underlying pathological p...

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Literature Corpus work: d322df11-4e80-597d-bb90-b59d0fa525a3
DOI: 10.1101/2024.01.04.574167

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