Article

Neuronal hyperactivity in a LRRK2-G2019S cellular model of Parkinson’s Disease

2021-06-23

Abstract excerpt

Monogenic Parkinson’s Disease can be caused by a mutation in the leucine-rich repeat kinase 2 (LRRK2) gene, causing a late-onset autosomal dominant inherited form of Parkinson’s Disease. The function of the LRRK2 gene is incompletely understood, but several in vitro studies have reported that LRRK2-G2019S mutations affect neurite branching, calcium homeostasis and mitochondrial function, but thus far, there have...

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Literature Corpus work: db213898-e8c6-5da1-8f26-da7fcf4be86d
DOI: 10.1101/2021.06.23.449591

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