Article

Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation

2023-05-18

Abstract excerpt

Given the pro and anti-geronic roles of the TGF-β superfamily in aging, we hypothesized that human longevity involves genetic variation in TGF-β signaling genes. Here we utilized a candidate functional genomic approach to identify and characterize functional variants in TGF- β signaling associated with human longevity. Targeted sequencing of 113 genes involved in aging- associated TGF- β signaling in an Ashkenazi...

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Identifiers and source

Literature Corpus work: 812bd78d-e553-55f4-a50a-7f8d67cb4a5d
DOI: 10.1101/2023.05.17.540984

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