Article

Cardiovascular disease risk factors induce mesenchymal features and senescence in cardiac endothelial cells

2020-10-23

Abstract excerpt

Aging, obesity, hypertension and physical inactivity are major risk factors for endothelial dysfunction and cardiovascular disease (CVD). We applied fluorescence-activated cell sorting (FACS), RNA sequencing and bioinformatic methods to investigate the common effects of CVD risk factors on cardiac endothelial cells (ECs). Aging, obesity and pressure overload all upregulated pathways related to TGF-β signaling and...

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Literature Corpus work: be6eeaf9-86e1-5671-b6a0-78704a832138
DOI: 10.1101/2020.10.21.349472

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