NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.

doi:10.1016/j.celrep.2016.12.009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.

Cell reports - 3 Jan 2017

Olsen Maria B, Hildrestrand Gunn A, Scheffler Katja, Vinge Leif Erik, Alfsnes Katrine, Palibrk Vuk, Wang Junbai, Neurauter Christine G, Luna Luisa, Johansen Jostein, Øgaard Jonas D S, Ohm Ingrid K, Slupphaug Geir, Kuśnierczyk Anna, Fiane Arnt E, Brorson Sverre-Henning, Zhang Lili, Gullestad Lars, Louch William E, Iversen Per Ole, Østlie Ingunn, Klungland Arne, Christensen Geir, Sjaastad Ivar, Sætrom Pål, Yndestad Arne, Aukrust Pål, Bjørås Magnar, Finsen Alexandra V

Abstract excerpt

Myocardial infarction (MI) triggers a reparative response involving fibroblast proliferation and differentiation driving extracellular matrix modulation necessary to form a stabilizing scar. Recently, it was shown that a genetic variant of the base excision repair enzyme NEIL3 was associated with increased risk of MI in humans. Here, we report elevated myocardial NEIL3 expression in heart failure patients and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methylcytosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connective Tissue Diseases

Share to Endodeoxyribonucleases

Share to Heart Failure

Share to Leukocytes

Share to Matrix Metalloproteinase 2

Share to Myofibroblasts

Share to N-Glycosyl Hydrolases

Source

Open in PubMed

Identifiers

PMID: 28052262
DOI: 10.1016/j.celrep.2016.12.009

Genes

NEIL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.PMID 28052262Read ↗

Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarctionSemantic proximity Read ↗

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease.Semantic proximity Read ↗

Multiomics reveals epigenetic control of fibroblast activity after myocardial infarction and a key role for RUNX transcription factorsSemantic proximity Read ↗

DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.Semantic proximity Read ↗

Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice.Semantic proximity Read ↗

Single-cell RNA sequencing reveals the potential role of Postn(+) fibroblasts in promoting the progression of myocardial fibrosis after myocardial infarctionSemantic proximity Read ↗

Distinct Epigenomic Features in End-Stage Failing Human HeartsSemantic proximity Read ↗

Epigenetics in Reactive and Reparative Cardiac Fibrogenesis: The Promise of Epigenetic Therapy.Semantic proximity Read ↗

Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expressionSemantic proximity Read ↗

Spatial multi-omic map of human myocardial infarctionSemantic proximity Read ↗

The novel cardiokine GDF3 predicts adverse fibrotic remodeling post-myocardial infarctionSemantic proximity Read ↗

Roles of Epigenetics in Cardiac Fibroblast Activation and FibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.