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Article

Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Turner Adam W, Martinuk Amy, Silva Anada, Lau Paulina, Nikpay Majid, Eriksson Per, Folkersen Lasse, Perisic Ljubica, Hedin Ulf, Soubeyrand Sebastien, McPherson Ruth

Abstract excerpt

OBJECTIVE: A recent genome-wide association study meta-analysis identified an intronic single nucleotide polymorphism in SMAD3, rs56062135C>T, the minor allele (T) which associates with protection from coronary artery disease. Relevant to atherosclerosis, SMAD3 is a key contributor to transforming growth factor-β pathway signaling. Here, we seek to identify ≥1 causal coronary artery disease-associated single...

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Share to Coronary Vessels
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

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Source

Identifiers

PMID: 26966274
DOI: 10.1161/ATVBAHA.116.307294

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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