DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.

doi:10.1016/j.atherosclerosis.2021.02.023

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Article

DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.

Atherosclerosis - 1 May 2021

Quiles-Jiménez Ana, Gregersen Ida, Segers Filip M, Skarpengland Tonje, Kroustallaki Penelope, Yang Kuan, Kong Xiang Yi, Lauritzen Knut H, Olsen Maria B, Karlsen Tom Rune, Nyman Tuula A, Sagen Ellen L, Bjerkeli Vigdis, Suganthan Rajikala, Nygård Ståle, Scheffler Katja, Prins Jurriën, Van der Veer Eric, Øgaard Jonas Ds, Fløisand Yngvar, Jørgensen Helle F, Holven Kirsten B, Biessen Erik A, Nilsen Hilde, Dahl Tuva B, Holm Sverre, Bennett Martin R, Aukrust Pål, Bjørås Magnar, Halvorsen Bente

Abstract excerpt

BACKGROUND AND AIMS: Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously been shown to have a role in atherogenesis, though whether this is due to its ability to repair DNA damage or to other non-canonical functions is not yet clear. Hereby, we investigate the role...

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PMID: 33714552
DOI: 10.1016/j.atherosclerosis.2021.02.023

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