Article

A ubiquitin-based mechanism for the oligogenic inheritance of heterotaxy and heart defects

2020-05-26

Abstract excerpt

The etiology of congenital heart defects (CHDs), amongst the most common human birth defects, is poorly understood partly because of its complex genetic architecture. Here we show that two genes previously implicated in CHDs, Megf8 and Mgrn1 , interact genetically and biochemically to regulate the strength of Hedgehog signaling in target cells. MEGF8, a single-pass transmembrane protein, and MGRN1, a RING superf...

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Literature Corpus work: 810fbf65-6fb0-5ee0-aa73-27d3b0b77441
DOI: 10.1101/2020.05.25.113944

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