Article
A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development.
Developmental cell - 23 Nov 2020
Kong Jennifer H, Young Cullen B, Pusapati Ganesh V, Patel Chandni B, Ho Sebastian, Krishnan Arunkumar, Lin Jiuann-Huey Ivy, Devine William, Moreau de Bellaing Anne, Athni Tejas S, Aravind L, Gunn Teresa M, Lo Cecilia W, Rohatgi Rajat
Abstract excerpt
The etiology of congenital heart defects (CHDs), which are among the most common human birth defects, is poorly understood because of its complex genetic architecture. Here, we show that two genes implicated in CHDs, Megf8 and Mgrn1, interact genetically and biochemically to regulate the strength of Hedgehog signaling in target cells. MEGF8, a transmembrane protein, and MGRN1, a RING superfamily E3 ligase,...
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