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Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque

2024-04-14

Abstract excerpt

Nanoparticles offer promise as a mechanism to non-invasively deliver targeted placental therapeutics. Our previous studies utilizing intraplacental administration demonstrate efficient nanoparticle uptake into placental trophoblast cells and overexpression of human IGF1 ( hIGF1 ). Nanoparticle-mediated placental overexpression of hIGF1 in small animal models of placental insufficiency and fetal growth restricti...

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Literature Corpus work
c7afb3b6-02f3-552a-ac62-e0e2af1fbfe6
DOI
10.1101/2024.04.10.588902
Open publication

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Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaqueDOI 10.1101/2024.04.10.588902
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