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Article

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.

Proceedings of the National Academy of Sciences of the United States of America - 7 Aug 2012

Park Daniel J, Lukens Amanda K, Neafsey Daniel E, Schaffner Stephen F, Chang Hsiao-Han, Valim Clarissa, Ribacke Ulf, Van Tyne Daria, Galinsky Kevin, Galligan Meghan, Becker Justin S, Ndiaye Daouda, Mboup Souleymane, Wiegand Roger C, Hartl Daniel L, Sabeti Pardis C, Wirth Dyann F, Volkman Sarah K

Abstract excerpt

Through rapid genetic adaptation and natural selection, the Plasmodium falciparum parasite--the deadliest of those that cause malaria--is able to develop resistance to antimalarial drugs, thwarting present efforts to control it. Genome-wide association studies (GWAS) provide a critical hypothesis-generating tool for understanding how this occurs. However, in P. falciparum, the limited amount of linkage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22826220
DOI: 10.1073/pnas.1210585109
PMCID: PMC3420184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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