Article

The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance

2025-02-20

Abstract excerpt

Circulating cell-free DNA (cfDNA) is a promising molecular biomarker. However, its utility in severe infection remains poorly understood. Here, we isolated cfDNA from sepsis patients and controls, demonstrating a 41-fold increase in the amount of cfDNA in circulation during disease. We used sequencing to reconstruct cfDNA methylomes, fragmentation profiles, and nucleosome footprints across 56 samples. We observed...

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Literature Corpus work: 80ecca08-950f-506e-ad7f-8c3db5c1d4f5
DOI: 10.1101/2025.02.17.638622

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