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Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs

19 Apr 2023

Abstract excerpt

Cell-free DNA (cfDNA) fragmentation is nonrandom, at least partially mediated by various DNA nucleases, forming characteristic cfDNA end motifs. However, there is a paucity of tools for deciphering the relative contributions of cfDNA cleavage patterns related to underlying fragmentation factors. In this study, through non-negative matrix factorization algorithm, we used 256 5' 4-mer end motifs to identify...

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PMID: 37075072
DOI: 10.1073/pnas.2220982120

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