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Article

Cell-free DNA size deconvolution resolves nucleosomal origins and reveals tumor-associated fragmentomic alterations.

Nature communications - 8 May 2026

Zhou Ze, Cooper Wendy N, Cheng Zhao, Lightowlers Sara, Coles Charlotte E, Roshan Amit, Rosenfeld Nitzan, Zhao Hui

Abstract excerpt

Analysis of cell-free DNA (cfDNA) fragmentomic features holds great promise for minimally invasive cancer diagnostics. Although selectively analyzing short plasma cfDNA enriches tumor-derived DNA (ctDNA), the mechanisms shaping cfDNA size profiles remain incompletely understood. Here, we develop a generalized model of cfDNA fragment length distributions across multiple bodily fluids (saliva, urine, cerebrospinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42103785
DOI: 10.1038/s41467-026-72925-4
PMCID: PMC13369908

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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