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Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

23 Nov 2018

Abstract excerpt

Methylation patterns of circulating cell-free DNA (cfDNA) contain rich information about recent cell death events in the body. Here, we present an approach for unbiased determination of the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types. The method is validated using in silico simulations as well as in vitro mixes of DNA from different tissue sources at known...

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PMID: 30498206
DOI: 10.1038/s41467-018-07466-6

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