Article

Clastogenesis by low densities of nucleotide lesions requires the completion of two cell cycles

2026-02-26

Abstract excerpt

<title>Abstract</title> <p>Damaged DNA nucleotides can trigger genome rearrangements through clastogenesis, a process driven by erroneous repair of double-strand breaks (DSBs) and associated with cancer development. While DSBs are known to arise from endonuclease activity at stalled replication forks, their clastogenic potential has remained uncertain. Here, we have used wild-type, nucleotide excision repair (NER...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80e1a039-f68e-5c33-a0e6-ce132268e16f
DOI: 10.21203/rs.3.rs-8902005/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clastogenesis by low densities of nucleotide lesions requires the completion of two cell cyclesDOI 10.21203/rs.3.rs-8902005/v1Read

Clastogenesis by nucleotide lesions requires the completion of two cell cyclesSemantic proximity Read

Preserving genome integrity in human cells via DNA double-strand break repairSemantic proximity Read

DNA double-strand break repair in a cellular context.Semantic proximity Read

DNA replication in the face of (In)surmountable odds.Semantic proximity Read

Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1-DNA crosslinksSemantic proximity Read

DNA damage responses protect xeroderma pigmentosum variant from UVC-induced clastogenesis.Semantic proximity Read

EXO1-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cellsSemantic proximity Read

Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errorsSemantic proximity Read

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier.Semantic proximity Read

Sensing and repairing DNA double-strand breaks.Semantic proximity Read

S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.Semantic proximity Read

Pathways for maintenance of telomeres and common fragile sites during DNA replication stressSemantic proximity Read