Article

Clastogenesis by nucleotide lesions requires the completion of two cell cycles

2025-12-18

Abstract excerpt

Damaged DNA nucleotides can trigger genome rearrangements through clastogenesis, a process driven by erroneous repair of double-strand breaks (DSBs) and associated with cancer development. While DSBs are known to arise from endonuclease activity at stalled replication forks, the clastogenic potential of such DSBs has remained uncertain. Here, we identify a previously unrecognized mechanism of clastogenesis using w...

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Literature Corpus work: 827b124d-3766-53fa-8fe0-835c8eeb5175
DOI: 10.64898/2025.12.16.694654

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