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Preserving genome integrity in human cells via DNA double-strand break repair

15 Apr 2020

Abstract excerpt

The efficient maintenance of genome integrity in the face of cellular stress is vital to protect against human diseases such as cancer. DNA replication, chromatin dynamics, cellular signaling, nuclear architecture, cell cycle checkpoints, and other cellular activities contribute to the delicate spatiotemporal control that cells utilize to regulate and maintain genome stability. This perspective will highlight DNA...

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PMID: 32286930
DOI: 10.1091/mbc.e18-10-0668

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