Article

The Epigenetic Factor PHF13 Governs Trophoblast Stemness and Differentiation

2026-03-17

Abstract excerpt

Differentiation of trophoblast stem (TS) cells or progenitor cytotrophoblasts (CTBs) into multinucleated syncytiotrophoblasts (STBs) is essential for placental development. Disruption of this process contributes to major obstetrical syndromes, including fetal growth restriction and preeclampsia, and Trisomy 21. However, the chromatin mechanisms governing trophoblast stemness and differentiation remain inadequately...

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Literature Corpus work: 80669138-fad4-520a-a150-2ba8fa85477c
DOI: 10.64898/2026.03.14.711150

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