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The GATA transcriptional program dictates cell fate equilibrium to establish the maternal–fetal exchange interface and fetal development

12 Feb 2024

Abstract excerpt

The placenta establishes a maternal-fetal exchange interface to transport nutrients and gases between the mother and the fetus. Establishment of this exchange interface relies on the development of multinucleated syncytiotrophoblasts (SynT) from trophoblast progenitors, and defect in SynT development often leads to pregnancy failure and impaired embryonic development. Here, we show that mouse embryos with...

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PMID: 38346193
DOI: 10.1073/pnas.2310502121

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