Article

GATA2 and GATA3 cooperate with BRG1 to specify human trophoblast identity through primate-specific elements

2026-06-05

Abstract excerpt

<title>Abstract</title> <p> Human placentation diverges substantially from rodent paradigms, yet the chromatin-level mechanisms directing human trophoblast specification remain poorly defined. Using <italic>GATA2/GATA3</italic> double-knockout human expanded potential stem cells (hEPSCs) and hEPSC-derived trophoblast stem cells (hTSCs), we show that joint loss abolishes trophoblast commitment and unexpectedly...

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Literature Corpus work: 94498b07-71b0-5f49-b5ec-55a9bf00317f
DOI: 10.21203/rs.3.rs-9929423/v1

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