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An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells

1 Jul 2022

Abstract excerpt

The trophoblast lineage safeguards fetal development by mediating embryo implantation, immune tolerance, nutritional supply and gas exchange. Human trophoblast stem cells (hTSCs) provide a platform to study lineage specification of placental tissues; however, the regulatory network controlling self-renewal remains elusive. Here, we present a single-cell atlas of human trophoblast development from zygote to...

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PMID: 35792865
DOI: 10.1242/dev.200171

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