Article

Active remodeling of the chromatin landscape directs extravillous trophoblast cell lineage development

2022-05-26

Abstract excerpt

<h4>ABSTRACT</h4> The extravillous trophoblast ( EVT ) cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving EVT cell development is limited. Here, we mapped the transcriptome and epigenome landscape as well as chromatin interactions of human trophoblast stem ( TS ) cells and their transition into EVT cells. Integration of chromatin accessibility, l...

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Literature Corpus work: 106c3cfe-a6dc-54f7-90d8-c7800dc981f5
DOI: 10.1101/2022.05.25.22275520

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