Article
The cumulative impact of passenger mutations on cancer development
2025-11-14
Abstract excerpt
The traditional binary classification of somatic mutations in cancer as either drivers or passengers overlooks the potential cumulative impact of smaller-effect mutations. Here, we analyze 2,263 whole-genome-sequenced primary tumors across 31 cancer types to assess the functional contribution of passenger mutations in cancer development. We find that in the absence of canonical driver mutations, passenger mutation...
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Identifiers and source
- Literature Corpus work
- 804ca21d-a5f3-5ef6-ae79-35ca300acae8
- DOI
- 10.1101/2025.11.13.688369