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Article

Impact of deleterious passenger mutations on cancer progression.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2013

McFarland Christopher D, Korolev Kirill S, Kryukov Gregory V, Sunyaev Shamil R, Mirny Leonid A

Abstract excerpt

Cancer progression is driven by the accumulation of a small number of genetic alterations. However, these few driver alterations reside in a cancer genome alongside tens of thousands of additional mutations termed passengers. Passengers are widely believed to have no role in cancer, yet many passengers fall within protein-coding genes and other functional elements that can have potentially deleterious effects on...

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Identifiers

PMID: 23388632
DOI: 10.1073/pnas.1213968110
PMCID: PMC3581883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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