Article
Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences.
Cell - 5 Mar 2020
Kumar Sushant, Warrell Jonathan, Li Shantao, McGillivray Patrick D, Meyerson William, Salichos Leonidas, Harmanci Arif, Martinez-Fundichely Alexander, Chan Calvin W Y, Nielsen Morten Muhlig, Lochovsky Lucas, Zhang Yan, Li Xiaotong, Lou Shaoke, Pedersen Jakob Skou, Herrmann Carl, Getz Gad, Khurana Ekta, Gerstein Mark B
Abstract excerpt
The dichotomous model of "drivers" and "passengers" in cancer posits that only a few mutations in a tumor strongly affect its progression, with the remaining ones being inconsequential. Here, we leveraged the comprehensive variant dataset from the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) project to demonstrate that-in addition to the dichotomy of high- and low-impact variants-there is a third group...
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