Article
Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era.
FEBS letters - 1 Dec 2020
Porta-Pardo Eduard, Valencia Alfonso, Godzik Adam
Abstract excerpt
One of the key challenges of cancer biology is to catalogue and understand the somatic genomic alterations leading to cancer. Although alternative definitions and search methods have been developed to identify cancer driver genes and mutations, analyses of thousands of cancer genomes return a remarkably similar catalogue of around 300 genes that are mutated in at least one cancer type. Yet, many features of these...
Topics
- Carcinogenesis
- Genomics
- Humans
- Mutation
- Neoplasms
- Oncogenes