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Article

Deciphering oncogenic drivers: from single genes to integrated pathways.

Briefings in bioinformatics - 1 May 2015

Chen Jiajia, Sun Maomin, Shen Bairong

Abstract excerpt

Technological advances in next-generation sequencing have uncovered a wide spectrum of aberrations in cancer genomes. The extreme diversity in cancer mutations necessitates computational approaches to differentiate between the 'drivers' with vital function in cancer progression and those nonfunctional 'passengers'. Although individual driver mutations are routinely identified, mutational profiles of different...

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Identifiers

PMID: 25378434
DOI: 10.1093/bib/bbu039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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