Article

PARP inhibitor synthetic lethality reveals homologous recombination sub-pathway architecture

2026-03-07

Abstract excerpt

The DNA damage response (DDR) is a complex network of interconnected pathways and sub-pathways that safeguards genome integrity. Deciphering the coordinated and complementary interactions among these pathways remains a major challenge. In this study, we employed CRISPR screening to systematically map the genetic interactions required for different sub-pathways of homologous recombination in human cells following P...

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Literature Corpus work: f982c040-d48d-582f-adc8-0da68c0272fe
DOI: 10.64898/2026.03.06.709881

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