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Article

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.

Nucleic acids research - 1 Feb 2014

Lee Michael, Hills Mark, Conomos Dimitri, Stutz Michael D, Dagg Rebecca A, Lau Loretta M S, Reddel Roger R, Pickett Hilda A

Abstract excerpt

Telomeres are terminal repetitive DNA sequences on chromosomes, and are considered to comprise almost exclusively hexameric TTAGGG repeats. We have evaluated telomere sequence content in human cells using whole-genome sequencing followed by telomere read extraction in a panel of mortal cell strains and immortal cell lines. We identified a wide range of telomere variant repeats in human cells, and found evidence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24225324
DOI: 10.1093/nar/gkt1117
PMCID: PMC3919612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.PMID 24225324Read ↗

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Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.Semantic proximity Read ↗

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