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Article

Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8.

Nature methods - 1 Apr 2006

Wang Gang G, Calvo Katherine R, Pasillas Martina P, Sykes David B, Häcker Hans, Kamps Mark P

Abstract excerpt

Differentiation mechanisms and inflammatory functions of neutrophils and macrophages are usually studied by genetic and biochemical approaches that require costly breeding and time-consuming purification to obtain phagocytes for functional analysis. Because Hox oncoproteins enforce self-renewal of factor-dependent myeloid progenitors, we queried whether estrogen-regulated Hoxb8 (ER-Hoxb8) could immortalize...

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PMID: 16554834
DOI: 10.1038/nmeth865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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