Article

Genetic variability in response to Aβ deposition influences Alzheimer’s risk

2018-10-08

Abstract excerpt

Genetic analysis of late-onset Alzheimer’s disease risk has previously identified a network of largely microglial genes that form a transcriptional network. In transgenic mouse models of amyloid deposition we have previously shown that the expression of many of the mouse orthologs of these genes are co-ordinately up-regulated by amyloid deposition. Here we investigate whether systematic analysis of other members o...

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Literature Corpus work: 7fbc3204-2113-5c59-bc1c-8c2361493662
DOI: 10.1101/437657

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