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Article

MOF maintains transcriptional programs regulating cellular stress response

21 Sept 2015

Abstract excerpt

MOF (MYST1, KAT8) is the major H4K16 lysine acetyltransferase (KAT) in Drosophila and mammals and is essential for embryonic development. However, little is known regarding the role of MOF in specific cell lineages. Here we analyze the differential role of MOF in proliferating and terminally differentiated tissues at steady state and under stress conditions. In proliferating cells, MOF directly binds and...

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PMID: 26387537
DOI: 10.1038/onc.2015.335

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