Article

Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes

2021-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Male sex is a risk factor for progression of diabetic kidney disease, but the reasons for this predilection are unclear. Here, we demonstrate that cell sex and sex hormones alter the metabolic phenotype of human proximal tubular epithelial cells (PTECs). Male PTECs displayed increased glycolysis, mitochondrial respiration, oxidative stress, apoptosis, and high glucose-induced injury, compared to...

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Literature Corpus work: 50ef9b70-e79d-5191-a7ad-ea9a6c50dddc
DOI: 10.1101/2021.08.23.457385

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