Article

Direct androgen receptor regulation of sexually dimorphic gene expression in the mammalian kidney

2023-05-06

Abstract excerpt

Mammalian organs exhibit distinct physiology, disease susceptibility and injury responses between the sexes. In the mouse kidney, sexually dimorphic gene activity maps predominantly to proximal tubule (PT) segments. Bulk RNA-seq data demonstrated sex differences were established from 4 and 8 weeks after birth under gonadal control. Hormone injection studies and genetic removal of androgen and estrogen receptors de...

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Literature Corpus work: 09ba89ee-0d22-5e6f-ad5b-1897059f693a
DOI: 10.1101/2023.05.06.539585

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