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Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan

21 Apr 2025

Abstract excerpt

There is a sex bias in the incidence and progression of many kidney diseases. To better understand such sexual dimorphism, we integrated data from six platforms, characterizing 76 kidney samples from 68 mice at six developmental and adult time points, creating a molecular atlas of the mouse kidney across the lifespan for both sexes. We show that proximal tubules have the most sex-biased differentially expressed...

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PMID: 40259083
DOI: 10.1038/s41588-025-02161-x

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