Article

Genome-wide landscape of RNA-binding protein dysregulation reveals a major impact on psychiatric disorder risk

2020-05-20

Abstract excerpt

Despite the strong genetic basis of psychiatric disorders, the molecular origins of these diseases are still largely unmapped. RNA-binding proteins (RBPs) are responsible for most post-transcriptional regulation, from splicing to translational to localization. RBPs thus act as key gatekeepers of cellular homeostasis, especially in the brain. Here, we leverage a deep learning approach to interrogate variant effects...

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Literature Corpus work: 7f8c07d5-3e8d-5bc7-a7fe-974fdccbf639
DOI: 10.1101/2020.05.19.102319

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