Article
Comprehensive RNA-binding protein analyses and deep learning uncover genetic constraints and disease associations in protein-RNA interfaces.
Cell systems - 17 Jun 2026
Her Hsuan-Lin, Yee Brian A, Xu Shuhao, Boyle Evan A, Rothamel Katherine L, Zhao Zia Z, Blue Steven M, Mueller Jasmine R, Park Samuel S, Nguyen Grady G, Naritomi Jack T, Klie Adam, Wei Xintao, Olson Sara, Zhan Lijun, Aigner Stefan, Graveley Brenton R, Yeo Gene W
Abstract excerpt
RNA-binding proteins (RBPs) orchestrate post-transcriptional processes, including splicing, cleavage and polyadenylation, and translation. Our updated RBP resource integrates data from 92 additional RBPs (286 in total) profiled by enhanced CLIP (eCLIP), enabling comprehensive characterization of RNA elements within human K562 and HepG2 cells. To interrogate RBP-binding syntax, we trained deep-learning models on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.