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Proteome-wide Association Study Provides Insights Into the Genetic Component of Protein Abundance in Psychiatric Disorders.

Biological psychiatry - 1 Dec 2021

Liu Jiewei, Li Xiaoyan, Luo Xiong-Jian

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified multiple risk variants for psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders remains largely unknown. METHODS: We performed proteome-wide association studies to identify genes whose cis-regulated protein abundance change in the human brain were associated with psychiatric disorders. RESULTS: By integrating...

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PMID: 34454697
DOI: 10.1016/j.biopsych.2021.06.022

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