Article

RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins

2018-11-19

Abstract excerpt

RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation and disease. Their binding sites cover more of the genome than coding exons; nevertheless, most noncoding variant-prioritization methods only focus on transcriptional regulation. Here, we integrate the portfolio of ENCODE-RBP experiments to develop RADAR, a variant-scoring framework. RADAR uses conservation, RNA structure, network centra...

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Literature Corpus work: 414a0fe0-8d1c-590a-b307-92a5dc47e9ca
DOI: 10.1101/474072

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