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Article

MicroRNA binding site variation is enriched in psychiatric disorders.

Human mutation - 1 Dec 2022

Geaghan Michael P, Reay William R, Cairns Murray J

Abstract excerpt

Psychiatric disorders have a polygenic architecture, often associated with dozens or hundreds of independent genomic loci. Most associated loci impact noncoding regions of the genome, suggesting that the majority of disease heritability originates from the disruption of regulatory sequences. While most research has focused on variants that modify regulatory DNA elements, those affecting cis-acting RNA sequences,...

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Identifiers

PMID: 36217923
DOI: 10.1002/humu.24481
PMCID: PMC10947041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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