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Article

Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders.

Biological psychiatry - 1 Jan 2021

Hernandez Leanna M, Kim Minsoo, Hoftman Gil D, Haney Jillian R, de la Torre-Ubieta Luis, Pasaniuc Bogdan, Gandal Michael J

Abstract excerpt

Over the past decade, large-scale genetic studies have successfully identified hundreds of genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic insight and clinical translation continue to lag the pace of risk variant identification, hindered by the sheer number of targets and their predominant noncoding localization, as well as pervasive pleiotropy and incomplete...

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Identifiers

PMID: 32792264
DOI: 10.1016/j.biopsych.2020.06.005
PMCID: PMC7718368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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