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Article

Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk.

Nature genetics - 1 Feb 2021

Park Christopher Y, Zhou Jian, Wong Aaron K, Chen Kathleen M, Theesfeld Chandra L, Darnell Robert B, Troyanskaya Olga G

Abstract excerpt

Despite the strong genetic basis of psychiatric disorders, the underlying molecular mechanisms are largely unmapped. RNA-binding proteins (RBPs) are responsible for most post-transcriptional regulation, from splicing to translation to localization. RBPs thus act as key gatekeepers of cellular homeostasis, especially in the brain. However, quantifying the pathogenic contribution of noncoding variants impacting RBP...

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Identifiers

PMID: 33462483
DOI: 10.1038/s41588-020-00761-3
PMCID: PMC7886016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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