Article

A novel CRISPR activation mouse enables modelling of aggressive lymphoma and interrogation of venetoclax resistance.

2021-09-10

Abstract excerpt

<title>Abstract</title> CRISPR technologies have advanced cancer modelling in mice, but CRISPR activation (CRISPRa) methods have not been thoroughly exploited in this context. Here we establish a CRISPRa mouse (dCas9a-SAMKI/+) for inducing gene expression in vivo and in vitro. Using dCas9a-SAMKI/KI primary lymphocytes, we induced B cell restricted genes in the T cell lineage and <italic>v...

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Literature Corpus work: 20eddae0-f790-50d9-909f-36ad02b85a73
DOI: 10.21203/rs.3.rs-856034/v1

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