Article

Metabolic alterations drive inflammatory phenotypes in CHIP-associated heart failure

2024-07-30

Abstract excerpt

<h4>Summary</h4> Mutations in DNA methyltransferase 3 alpha (DNMT3A) are the most frequent driver of clonal hematopoiesis of indeterminate potential (CHIP), and associated with higher risk of cardiovascular disease and pro-inflammatory activation of immune cells. Here, we investigated the mechanisms underlying DNMT3A CHIP-associated inflammatory phenotypes in macrophages. We show that monocytes of DNMT3A CHIP-d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7f7e3abe-6e22-5a32-b2a5-986ec4460b49
DOI: 10.1101/2024.07.30.605744

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic alterations drive inflammatory phenotypes in CHIP-associated heart failureDOI 10.1101/2024.07.30.605744Read

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblastsSemantic proximity Read

Cell-intrinsic effects of clonal hematopoiesis in heart failure.Semantic proximity Read

Haematopoietic loss of KDM6A impairs cardiac recovery in heart failure <i>via</i> epigenetic reprogramming of myeloid cellsSemantic proximity Read

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis.Semantic proximity Read

The Role of Clonal Hematopoiesis of Indeterminant Potential and DNA (Cytosine-5)-Methyltransferase Dysregulation in Pulmonary Arterial Hypertension and Other Cardiovascular DiseasesSemantic proximity Read

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts.Semantic proximity Read

Metformin reduces the clonal fitness of Dnmt3aR878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic stateSemantic proximity Read

The transcriptome of CMML monocytes is highly inflammatory and reflects leukemia-specific and age-related alterations.Semantic proximity Read

Clonal hematopoiesis, inflammation, and cardiovascular disorders: a mitochondrial connection.Semantic proximity Read

Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.Semantic proximity Read

Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD.Semantic proximity Read

Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease developmentSemantic proximity Read