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Article

The transcriptome of CMML monocytes is highly inflammatory and reflects leukemia-specific and age-related alterations.

Blood advances - 22 Oct 2019

Franzini Anca, Pomicter Anthony D, Yan Dongqing, Khorashad Jamshid S, Tantravahi Srinivas K, Than Hein, Ahmann Jonathan M, O'Hare Thomas, Deininger Michael W

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) is an aggressive myeloid neoplasm of older individuals characterized by persistent monocytosis. Somatic mutations in CMML are heterogeneous and only partially explain the variability in clinical outcomes. Recent data suggest that cardiovascular morbidity is increased in CMML and contributes to reduced survival. Clonal hematopoiesis of indeterminate potential (CHIP), the...

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Identifiers

PMID: 31648319
DOI: 10.1182/bloodadvances.2019000585
PMCID: PMC6849944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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