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Article

Cell-intrinsic effects of clonal hematopoiesis in heart failure.

Nature cardiovascular research - 1 Sept 2023

Abplanalp Wesley T, Schuhmacher Bianca, Cremer Sebastian, Merten Maximilian, Shumliakivska Mariana, Macinkovic Igor, Zeiher Andreas M, John David, Dimmeler Stefanie

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is caused by somatic mutations in hematopoietic stem cells and associates with worse prognosis in patients with heart failure. Patients harboring CHIP mutations show enhanced inflammation. However, whether these signatures are derived from the relatively low number of cells harboring mutations or are indicators of systemic pro-inflammatory activation that is...

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Share to Clonal Hematopoiesis
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39196061
DOI: 10.1038/s44161-023-00322-x
PMCID: PMC11357996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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