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Article

Clonal hematopoiesis, inflammation, and cardiovascular disorders: a mitochondrial connection.

Trends in immunology - 1 Sept 2022

Pileri Francesco, Natoli Gioacchino

Abstract excerpt

Mutations in two antagonistic regulators of DNA methylation, DNMT3A and TET2, are associated with clonal hematopoiesis and increased risk of cardiovascular disorders. Recently, Cobo et al. traced the mechanistic bases for such links to loss of mitochondrial integrity, cytoplasmic dispersion of mitochondrial DNA, and the subsequent activation of interferon-stimulated genes (ISGs) in macrophages.

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Identifiers

PMID: 35945112
DOI: 10.1016/j.it.2022.07.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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