DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts.

doi:10.1038/s41467-023-43003-w

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Article

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts.

Nature communications - 19 Jan 2024

Shumliakivska Mariana, Luxán Guillermo, Hemmerling Inga, Scheller Marina, Li Xue, Müller-Tidow Carsten, Schuhmacher Bianca, Sun Zhengwu, Dendorfer Andreas, Debes Alisa, Glaser Simone-Franziska, Muhly-Reinholz Marion, Kirschbaum Klara, Hoffmann Jedrzej, Nagel Eike, Puntmann Valentina O, Cremer Sebastian, Leuschner Florian, Abplanalp Wesley Tyler, John David, Zeiher Andreas M, Dimmeler Stefanie

Abstract excerpt

Hematopoietic mutations in epigenetic regulators like DNA methyltransferase 3 alpha (DNMT3A), play a pivotal role in driving clonal hematopoiesis of indeterminate potential (CHIP), and are associated with unfavorable outcomes in patients suffering from heart failure (HF). However, the precise interactions between CHIP-mutated cells and other cardiac cell types remain unknown. Here, we identify fibroblasts as...

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Identifiers

PMID: 38242884
DOI: 10.1038/s41467-023-43003-w
PMCID: PMC10799021

Genes

DNMT3A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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