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Article

Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD.

Cells - 5 Jul 2022

Kuhnert Stefan, Mansouri Siavash, Rieger Michael A, Savai Rajkumar, Avci Edibe, Díaz-Piña Gabriela, Padmasekar Manju, Looso Mario, Hadzic Stefan, Acker Till, Klatt Stephan, Wilhelm Jochen, Fleming Ingrid, Sommer Natascha, Weissmann Norbert, Vogelmeier Claus, Bals Robert, Zeiher Andreas, Dimmeler Stefanie, Seeger Werner, Pullamsetti Soni S

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate potential (CHIP). The association between CHIP and COPD and its relevant effects on DNA methylation in aging are mainly unknown. Analyzing the deep-targeted amplicon...

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Identifiers

PMID: 35805204
DOI: 10.3390/cells11132121
PMCID: PMC9265467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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